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2 edition of comparison of the molecular cytotoxic mechanisms of copper and cadmium found in the catalog.

comparison of the molecular cytotoxic mechanisms of copper and cadmium

Jalal Pourahmadjaktaji

comparison of the molecular cytotoxic mechanisms of copper and cadmium

  • 12 Want to read
  • 28 Currently reading

Published .
Written in English


The Physical Object
Pagination1 v., 101 leaves
Number of Pages101
ID Numbers
Open LibraryOL19076281M
ISBN 100612408590

CAMAKARIS J, VOSKOBOINIK I, MERCER JF () Molecular mechanisms of copper homeostasis. Biochem Biophys Res Commun [ Links ] CHAN PK, CHENG SH () Cadmium-induced ectopic apoptosis in zebrafish embryos. Arch Toxicol [ Links ] CHEN WY, JOHN J A, LIN C H, LIN HF, WU SC, LIN CH, CHANG CY. Treatment of advanced breast cancer remains challenging. Copper and some of the copper-dependent proteins are emerging therapeutic targets because they are essential for cell proliferation and survival, and have been shown to stimulate angiogenesis and metastasis. Here, we show that DCAC50, a recently developed small-molecule inhibitor of the intracellular copper chaperones, ATOX1 and CCS.


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comparison of the molecular cytotoxic mechanisms of copper and cadmium by Jalal Pourahmadjaktaji Download PDF EPUB FB2

The Cytotoxic Effects of Cadmium on Human Breast MDA-MB Cell Line. MTT cell viability test was used to study the cytotoxic effects of cadmium chloride. Treatment of cultured monolayer cells with different metal concentrations ( µM) showed a significant time-dependent decrease (p Cited by: 8.

The phytotoxic effects of copper (Cu) and cadmium (Cd) on plant growth are well documented. However, Cu and Cd toxicity targets and the cellular systems contributing to acquisition of tolerance are not fully understood at the molecular level.

We aimed to identify genes and pathways that discriminate the actions of Cu and Cd in rice roots (Oryza sativa L. TN67).Cited by:   Cadmium is a complete carcinogen in experimental animals but because of its multiple molecular targets there is no simple mechanism of carcinogenesis.

In terms of a multi-stage model of transformation to tumors, initiation by gene mutation, promotion by stimulation of cell proliferation and further progression to tumor cells are to be by: The cytotoxic mechanisms of Disulfiram and copper(II) in cancer cells molecular anticancer mechanisms of DS include inhibition of viability was observed in ALDH + cells in comparison to.

The cytotoxic mechanisms of disulfiram and copper(II) in cancer cells Patricia Erebi Tawari,†a Zhipeng Wang,†a Mohammad Najlah,b Chi Wai Tsang,c Vinodh Kannappan,a Peng Liu,a Christopher McConville,e Bin He,d Angel L.

Armesillaa and Weiguang Wang*a The anticancer activity of disulfiram (DS) is copper(II) (Cu) by:   Recent studies have shown that ionic cadmium (Cd2+) can selectively damage the tight junctions between LLC-PK1 cells.

The objective of the present stu. Synonyms, trade names and molecular formulae for cadmium, cadmium–copper alloy, and some cadmium compounds are presented in Table The cadmium compounds shown are those for which data on carcinogenicity or muta - genicity were available or which are commercially important compounds.

It is not an exhaustive list. Molecular mechanisms of cadmium induced mutagenicity Studies on cytotoxic and genotoxic effects of cadmium nitrate and lead nitrate in Chinese hamster ovary cells. Molecular analysis and comparison of radiation-induced large deletions of the HPRT locus in primary human skin fibroblasts.

The widespread occurrence of cadmium in the environment continues to pose a threat to human health despite attempts at limiting its technological uses. The biologically significant ionic form of comparison of the molecular cytotoxic mechanisms of copper and cadmium book, Cd2+, binds to many bio-molecules and these interactions underlie the toxicity mechanisms of cadmium.

Some of the molecules specialized in the handling of alkaline earth (Mg2+, Ca2+) and. The aim of this study was to determine the cellular and molecular mechanisms of cell death induced by mammea A/BA and A/BB (3: 1) on K cells.

showed cytotoxic activity against K cells. A low-shoot-Cd (QLQ) and a high-shoot-Cd cultivar (T) of water spinach (Ipomoea aquatica Forsk.) were used to investigate molecular mechanism of the genotype difference in cadmium (Cd.

comparison with those people living farther away from the cadmium sources (Hellstrom molecular mechanisms by which Cd is taken up by proximal tubule epithelial cells Mechanisms in cadmium.

Cd 2+ can displace and replace zinc in these motifs and disrupt target proteins as suggested by the fact that addition of zinc, during or after intoxication by cadmium, can reverse the effects of cadmium exposure.

Another proposed mechanism cadmium intoxication is a cadmium-mediated production of ROS, leading to oxidation of cysteine residues. Copper is an essential trace element within cells, but it also exerts cytotoxic effects through induction of reactive oxygen species (ROS) production.

To determine the mechanisms underlying copper-induced ROS production, we examined the effects of copper sulfate in HeLa cells.

Exposure to copper sulfate led to dose-dependent decreases in HeLa cell viability, along with increases in the subG1. Cadmium is a heavy metal thatoccurs as a natural constituent in earth’s crust along with Copper, Lead, Nickel and Zinc. Cadmium is vastly used in batteries, coating, plating, alloys etc.

in various industries. Humans arecommonly exposed to cadmium by inhalation and ingestion through Cigarettes, Batteries and other factors. The aim of the study was to compare the features of cytotoxic and genotoxic effects of cadmium sulfide (CdS) NPs of different sizes on cell cultures of different histogenesis with those of cadmium.

Cadmium (Cd) is a heavy metal considered as one of the main toxic pollutants in the environment and affects several metabolic processes in plants and animals, justifying scientific efforts to study Cd bioremediation and biochemical, physiological, and molecular mechanisms of plant response and tolerance to cope with Cd toxicity.

However, limited understanding of their molecular mechanisms of cytotoxic action greatly hinders their further development as anticancer agents. In this study, a lead platinum-based metallointercalator, [(5,6-dimethyl-1,phenanthroline) (1 S,2 S -diaminocyclohexane)platinum(II)] 2+ (56MESS) was found to be fold more active than cisplatin.

The newest information on the molecular signaling and epigenetic mechanisms of nickel’s action in biological systems is briefly summarized herein and more in-depth knowledge can be gained from a recent review (Chervona et al., ), as well as from Chapter 9 of this handbook, “Selected Molecular Mechanisms of Metal Toxicity and.

The cadmium/zinc hyperaccumulator Thlaspi caerulescens is sensitive toward copper (Cu) toxicity, which is a problem for phytoremediation of soils with mixed contamination.

Cu levels in T. caerulescens grown with 10 μ m Cu2+ remained in the nonaccumulator range. The chemistry of copper is dominated by the +2 oxidation state, for example, copper(II) complex ions. In comparison with other divalent first-row transition-metal aqua ions, the [Cu(H 2 O) 6] 2+ ion is extremely labile [41, 42].

This effect is a consequence of Jahn-Teller distortion. The toxicity mechanisms of copper, lead and cadmium in freshwater, brine water and saltwater gave rise to a clearer understanding of the activation of stress-inducible heat shock proteins.

The regulation of HSP60, HSP70, HSP90 and small Hsp by some redox-inactive metals occurred as a function of dose concentration and duration of chemical assault. The cadmium/zinc hyperaccumulator Thlaspi caerulescens is sensitive toward copper (Cu) toxicity, which is a problem for phytoremediation of soils with mixed contamination.

Cu levels in T. caerulescens grown with 10 μ m Cu 2+ remained in the nonaccumulator range. sensitizes them to cadmium's cytotoxic effects. GSH thus may be involved in modulating the early cellular Cd** cytotoxic response. Comparison of reduced GSH levels and of Cd** cytotoxic responses in BSO-treated AT27 cells with those levels in other, untreated normal and tumor-derived cells suggests that the higher level of GSH in AT27 is.

Copper and cadmium-induced MAPK signaling pathways. Excess copper and cadmium ions induce distinct MAPK pathways with different kinetics. A, As a redox-active metal ion, copper leads to the production of ROS that might trigger SIMK and SAMK activation via SIMKK.

B, Cadmium activates SIMK, MMK2, MMK3, and SAMK. Poor root growth is caused by various rhizotoxic factors present in problem soils, and is linked to susceptibility to other stress factors.

For example, aluminum (Al) ions cause severe damage to the roots of plants growing in acid soil, accentuating nutrient deficiency and increasing their sensitivity to drought stress [].Other metal rhizotoxins, such as cadmium (Cd) and copper (Cu) ions, also.

Cadmium is known to modulate gene expression and signal transduction (Waisberg et al. Carcinogenicity: There is sufficient evidence that cadmium metal and a number of cadmium compounds, such as cadmium chloride, oxide, sulfate, and sulfide, are carcinogenic in animals.

Cadmium is a widespread toxic pollutant of occupational and environmental concern because of its diverse toxic effects: extremely protracted biological half-life (approximately 20–30 years in humans), low rate of excretion from the body and storage predominantly in soft tissues (primarily, liver and kidneys).

Since life-cycle studies showed that the earthworm species Eisenia fetida can develop increased tolerance after long-term exposure to a sub-lethal concentration of Cd in the laboratory, we assessed both the cytotoxicity and genotoxicity of Cd in a long-term Cd-exposed population.

We exposed E. fetida specimens from this population, from a laboratory control population and from a field. More cadmium in the mixture decreased the toxicity and more copper increased the toxicity. The effect of copper‐carbendazim on reproduction was synergistic at low dose levels and antagonistic at high dose levels and independent of time.

Mixture effects on the juvenile and reproductive period were similar to single component effects. @article{osti_, title = {Pharmacologic modification of the cytotoxic effects of cadmium in LLC-PK sub 1 cells}, author = {Battaglia, D R and Kahan, B S and Niewenhuis, R J and Prozialeck, W C}, abstractNote = {Recent results from our laboratories have shown that exposure to cadmium causes LLC-PK{sub 1} cells to shrink, detach and assume a spherical shape.

Copper is a chemical element with the symbol Cu (from Latin: cuprum) and atomic number It is a soft, malleable, and ductile metal with very high thermal and electrical conductivity.A freshly exposed surface of pure copper has a pinkish-orange is used as a conductor of heat and electricity, as a building material, and as a constituent of various metal alloys, such as sterling.

Bacteria are rapidly killed on copper surfaces, and copper ions released from the surface have been proposed to play a major role in the killing process. However, it has remained unclear whether contact of the bacteria with the copper surface is also an important factor.

Using laser interference lithography, we engineered copper surfaces which were covered with a grid of an inert polymer which. Results. Roots of Arabidopsis were treated with the major rhizotoxic stressors, aluminum (Al) ions, cadmium (Cd) ions, copper (Cu) ions and sodium (NaCl) chloride, and the gene expression responses were analyzed by DNA array top % of genes whose expression was most increased by each stressor were compared with identify common and specific gene expression responses.

There has been increased concern surrounding exposure to heavy metals due to the evolving understanding of their role in the development of cancer. This review highlights research related to the impact that heavy metals aluminum, arsenic, beryllium, cadmium, lead, mercury, nickel and radium have on human health.

Research was collected through PubMed, and it was compiled to assess the. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism.

Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. Hypopigmentation is a feature of copper deficiency in humans, as caused by mutation of the copper (Cu2+) transporter ATP7A in Menkes disease, or an inability to absorb copper after gastric surgery.

However, many causes of copper deficiency are unknown, and genetic polymorphisms might underlie sensitivity to suboptimal environmental copper conditions.

Cadmium (Cd) is toxic to plant cells. Under Cd exposure, the plant displayed leaf chlorosis, which is a typical symptom of iron (Fe) deficiency. Interactions of Cd with Fe have been reported. However, the molecular mechanisms of Cd-Fe interactions are not well understood. Here, we showed that FER-like Deficiency Induced Transcripition Factor (FIT), AtbHLH38, and AtbHLH39, three basic helix.

However, its extent as well as molecular mechanisms involved in cadmium carcinogenesis has yet to be fully clarified. To this end, we used the zinc specific probe Zinquin to visualize and to quantitatively evaluate changes in the concentration of labile zinc, in an in vitro model of human hepatic cells (HepG2) exposed to cadmium.

For many years, it has been known that cadmium (Cd), a ubiquitous heavy metal and an environmental pollutant, is highly cytotoxic.

A number of studies have shown that it may induce either necrosis or apoptosis, depending on the exposure conditions and the model used (Galan et al., ; Ishido et al., ).Many investigators have studied the ability of Cd to affect cellular function.

Oxidative stress, which is the loss of balance between antioxidant defense and oxidant production in the cells, is implicated in the molecular mechanism of heavy metal-induced neurotoxicity.

Given the key role of lead (Pb) and cadmium (Cd) in inducing oxidative stress, we investigated their role in disrupting the integrity and function of immortalized human brain microvascular endothelial.Cadmium is classified as a human carcinogen, and its disturbance in zinc homeostasis has been well established.

However, its extent as well as molecular mechanisms involved in cadmium carcinogenesis has yet to be fully clarified. To this end, we used the zinc specific probe Zinquin to visualize and to quantitatively evaluate changes in the concentration of labile zinc, in an in vitro.Abstract.

The mechanisms underlying the cytotoxic action of pure fullerene suspension (nano-C 60) and water-soluble polyhydroxylated fullerene [C 60 (OH) n] were l violet assay for cell viability demonstrated that nano-C 60 was at least three orders of magnitude more toxic than C 60 (OH) n to mouse L fibrosarcoma, rat C6 glioma, and U human glioma cell lines.